Specific CCND1 G870A alleles associated with breast cancer susceptibility: a meta-analysis of 5,528 cases and 5,353 controls.

BACKGROUND The Cyclin D1(CCND1) G870A polymorphism may be associated with breast cancer, but the evidence from individual studies is inconclusive. The aim of this study was to investigate the correlation between the CCND1 G870A polymorphism and breast cancer risk in a meta-analysis. MATERIALS AND METHODS We searched Pubmed and analysed 11 articles on 5,528 cases and 5,353 controls before February 1, 2012. RESULTS we found there are significant association for AA versus GG and AA versus GA/GG. No significant associations were found for GA versus GG, GA/AA versus GG. There are significant association for AA versus GG ,and AA versus GA/GG in Caucasians. We didn't find any significant main effects for G870A polymorphism on breast cancer risk either in recessive or dominant models in Asians. CONCLUSION This meta-analysis suggests that AA of the CCND1 G870A polymorphism is associated with breast cancer susceptibility.